Red Dragons are similar to typical story book dragons. They shoot flames, can fly, etc. However, they aren’t evil creatures as depicted in myths and won’t go around raiding castles, killing knights, or kidnapping princesses. They live in a variety of habitats, from forests to coastlines to abandoned castles, usually in warm climates, and eat whatever living creatures they can find.

Dragons are highly-intelligent reptilian creatures that—from a human perspective, at least—appear to live forever. Many different varieties of dragon exist, each with their own unique qualities, habitats, and behavior. Adolescence in dragons is usually marked by the growth of a hatchling’s wings, although not all breeds of dragons grow wings and some breeds have other traits that indicate the beginning of maturation. In Galsreim, dragons and humans coexist peacefully.

Doctor Horrible considers himself to be a criminal mastermind, although he hasn't quite figured out what that means yet. He spends a lot of time with Wonderflonia plotting what he claims are "diabolical deeds," but so far all he's accomplished is the liberation of a few pocket watches and a rockslide which may have been accidental and only succeeded in irritating the neighboring vine dragons. Lately he's been heard humming as he gathers supplies for his latest project, whatever that may be.